Доклад Dr. Alexey Nesvizhskii

Proteomics and Proteogenomics in Cancer Research

Alexey Nesvizhskii, University of Michigan, Ann Arbor, MI

Abstract:

My laboratory (www.nesvilab.org) is working in the areas of proteomics, transcriptomics, and integrative bioinformatics, with many applications in cancer research. We have developed widely used bioinformatics tools for mass spectrometry-based proteomics, protein-protein interaction analysis, proteogenomics, metabolomics, and multi-omics data integration (RNA-Seq, proteomics, genomics, etc.). One of our main interests is proteogenomics - an area of research at the interface of proteomics and genomics. In my presentation, I will present our work in several areas: (1) combined analysis of transcriptome and proteome data taking advantage of new technologies such as next-generation transcriptome sequencing (RNA-Seq) and highly sensitive mass spectrometry instrumentation; (2) protein level detection of novel peptides and peptide variants predicted using genomic and transcriptomic data; (3) reconstruction of targetable pathways in cancer using network-based integration of genomics, transcriptomics, and proteomics data. I will also present an update on our efforts to build a comprehensive proteogenomics pipeline in support of the Clinical Proteomics Clinical Proteomic Tumor Analysis Consortium (CPTAC https://proteomics.cancer.gov/programs/cptacnetwork).

13-е марта, 13-00,  Главное здание СПбГУ, 133 ауд.

 

 

 

Место: 
СПбГУ, ИТБМ