Proteomics and Proteogenomics in Cancer Research
Alexey Nesvizhskii, University of Michigan, Ann Arbor, MI
My laboratory (www.nesvilab.org) is working in the areas of proteomics, transcriptomics, and integrative bioinformatics, with many applications in cancer research. We have developed widely used bioinformatics tools for mass spectrometry-based proteomics, protein-protein interaction analysis, proteogenomics, metabolomics, and multi-omics data integration (RNA-Seq, proteomics, genomics, etc.). One of our main interests is proteogenomics - an area of research at the interface of proteomics and genomics. In my presentation, I will present our work in several areas: (1) combined analysis of transcriptome and proteome data taking advantage of new technologies such as next-generation transcriptome sequencing (RNA-Seq) and highly sensitive mass spectrometry instrumentation; (2) protein level detection of novel peptides and peptide variants predicted using genomic and transcriptomic data; (3) reconstruction of targetable pathways in cancer using network-based integration of genomics, transcriptomics, and proteomics data. I will also present an update on our efforts to build a comprehensive proteogenomics pipeline in support of the Clinical Proteomics Clinical Proteomic Tumor Analysis Consortium (CPTAC https://proteomics.cancer.gov/programs/cptacnetwork).
13-е марта, 13-00, Главное здание СПбГУ, 133 ауд.