Pavel E. Мusienko

Professor, Head of Neuroprosthetics Laboratory
PhD, MD, DSci
 
 
Current positions:

 
Head of Neuroprosthetics Lab, Institute of Translational Biomedicine, Saint-Petersburg State University, Russia
Head of Neurophysiology and Experimental Neurorehabilitation Lab, Children's Surgery and Orthopedic Clinic, Department of Non-pulmonary Tuberculosis, Institute of Phthysiopulmonology, St Petersburg, Russia
Senior researcher, Motor physiology laboratory, Pavlov Institute of Physiology, Russian Academy of Science
 
Date of birth: January 19, 1978
Place of birth: St.-Petersburg, Russia
 
 
Professional experience
 
1. Junior scientist at the Laboratory of Movement Physiology Pavlov Institute of Physiology, Russian Academy of Sciences (2002- 2005)
2. Research Associate at the Laboratory of Movement Physiology Pavlov Institute of Physiology, Russian Academy of Sciences (2002- 2012)
3. Researcher at the Laboratory of Movement Physiology Pavlov Institute of Physiology, Russian Academy of Sciences (2013-2015)
3. Doctor of medical sciences (doctoral dissertation "Spinal-brain stem mechanisms of posture and locomotion integrative control", defended on May 2014)
4. Professor, Head of Neuroprosthetics Lab, Institute of Translational Biomedicine, Saint-Petersburg State University (Oct, 2015-present)
 
 
Research interests
 
⋅ Spinal and brainstem mechanisms of the postural and locomotor control
⋅ Functional Electrical Stimulation, Spinal cord stimulation
⋅ Pathophysiology of spinal cord injuries (SCI)
⋅ Neurorehabiltiation interventions to restore the motor function after neuromotor desorders
⋅ Cortico-spinal neuroprostheses
 
 
Grants principal investigator (PI) experience
 
• Russian fundation of basic research (RFBR) grant 08-04-00688 (2008-2010)
• Russian fundation of basic research (RFBR) grant 11-04-01669 (2010-2012)
• Russian fundation of basic research (RFBR) grant 12-04-33145 (2012-2013)
• Grant of the President of the Russian Federation MK-5684.2012.4 (2012-2013)
• Russian science foundation (RSF) grant 14-15-00788 (2014-2016)
• Grant of President of Russian Federation (МD-1018.2017.7)

• Russian Foundation for Basic Research Grants17-29-01034-OFI-M (2017-2019)
• Russian Foundation for Basic Research Grants 17-04-01822-А (2017-2019)

 

 
Publication activity

 
Web of Science/Scopus publications – 45
Citations – 1532

i10-index – 25

 

 

Selected publications:
 
1.Courtine G., Gerasimenko Y., van den Brand R., Yew A., Musienko P., Zhong H., Song B., Ao Y., Ichiyama R.M., Lavrov I., Roy R.R., Sofroniew M.V., Edgerton V.R. Transformation of nonfunctional spinal circuits into functional states after the loss of brain input // Nature Neuroscience. – 2009. – Т. 12. – №. 10. – С. 1333-1342.
 
2.van den Brand R., Heutschi J., Barraud Q., DiGiovanna J., Bartholdi K., Huerlimann M., Friedli L., Vollenweider I., Moraud E.M., Duis S., Dominici N., Micera S., 
Musienko P., Courtine G. Restoring voluntary control of locomotion after paralyzing spinal cord injury // Science. – 2012. – Т. 336. – №. 6085. – С. 1182-1185.
 
3.Dominici N., Keller U., Vallery H., Friedli L., van den Brand R., Starkey M.L., Musienko P., Riener R., Courtine G. Versatile robotic interface to evaluate, enable and train locomotion and balance after neuromotor disorders // Nature Medicine. – 2012. – Т. 18. – №. 7. – С. 1142-1147.
 
4.Courtine G, van den Brand R, Musienko P. Spinal cord injury: time to move. Lancet. 2011, 377(9781):1896-8.
 
5.Wenger N, Moraud EM, Raspopovic S, Bonizzato M, DiGiovanna J, Musienko P, Morari M, Micera S, Courtine G. Closed-loop neuromodulation of spinal sensorimotor circuits controls refined locomotion after complete spinal cord injury. // Science Translational Medicine. – 2014. –  6(255): 255ra133. 
 
6. Minev I.R.*, Musienko P.* et al. Electronic dura mater for long-term multimodal neural interfaces. // Science. - 2015. - Vol. 347 no. 6218. - P.159-163.[* contributed equally].
 
7.Friedli L, Rosenzweig ES, Barraud Q, Schubert M, Dominici N, Awai L, Nielson JL, Musienko P, Nout-Lomas Y, Zhong H, Zdunowski S, Roy RR, Strand SC, van den Brand R, Havton LA, Beattie MS, Bresnahan JC, Bézard E, Bloch J, Edgerton VR, Ferguson AR, Curt A, Tuszynski MH, Courtine G. Pronounced species divergence in corticospinal tract reorganization and functional recovery after lateralized spinal cord injury favors primates. // Science Translational Medicine  2015; 7(302): 302ra134.
 
8. Wenger N., Moraud E.M., Gandar J., Musienko P. et al. Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury //  Nature Medicine. – 2016 – 22 (2), 138-145. 
 
All peer reviewed papers: 
 
1. Wenger N., Moraud E.M., Gandar J., Musienko P. et al. Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury //  Nature Medicine. – 2016 – 22 (2), 138-145. 
2. Merkulyeva N., Veshchitskii  A., Makarov F., Gerasimenko Y, Musienko Р. Distribution of 28 kDa calbindin-immunopositive neurons in the cat spinal cord // Frontier in Neuroanatomy. - 2016. 28(9):166.
3. Friedli L, Rosenzweig ES, Barraud Q, Schubert M, Dominici N, Awai L, Nielson JL, Musienko P, Nout-Lomas Y, Zhong H, Zdunowski S, Roy RR, Strand SC, van den Brand R, Havton LA, Beattie MS, Bresnahan JC, Bézard E, Bloch J, Edgerton VR, Ferguson AR, Curt A, Tuszynski MH, Courtine G. Pronounced species divergence in corticospinal tract reorganization and functional recovery after lateralized spinal cord injury favors primates. // Sci Transl Med. 2015; 7(302): 302ra134.
4. Lyakhovetskii VA, Gorskii OV, Gerasimenko YP, Musienko PE. Mathematical model of the hindlimbs control during cat locomotion with balance. // Ross Fiziol Zh Im I M Sechenova. 2015; 101(2): 200-13. Russian.
5. Lavrov I, Musienko PE, Selionov VA, Zdunowski S, Roy RR, Reggie Edgerton V, Gerasimenko Y. // Brain Res. 2015;1600: 84-92.
6. Minev I.R.*, Musienko P.* et al. Electronic dura mater for long-term multimodal neural interfaces. // Science. - 2015. - Vol. 347 no. 6218. - P.159-163. [* contributed equally]
7. Lyakhovetskii V, Gorskii O, Gerasimenko Y, Musienko P. Mathematical model of the hindlimbs control during cat locomotion with balance // Ross Fiziol Zh Im I M Sechenova. - 2015. - 101(2): 200-213.
8. Musienko P.E., Deliagina T.G., Gerasimenko Y.P., Orlovsky G.N., Zelenin P.V. Limb and trunk mechanisms for balance control during locomotion in quadrupeds // J Neurosci. – 2014. – 34(16) – 5704-16.
9. Courtine G., Musienko P., Barroud Q. “Pharmacological stimulation to facilitate and restore standing and walking functions in spinal cord disorders". Publication Date 7.01.2015. E.U. Patent №20130174477.
10. Borton D., Bonizzato M., Beauparlant J., Digiovanna J., Moraud E.M., Wenger N., Musienko P., Minev I.R., Lacour S.P., Millán J.D., Micera S., Courtine G. Corticospinal neuroprostheses to restore locomotion after spinal cord injury // Neuroscience Research. – 2014 – Vol. 78. – P. 21–29. Review.
11. Wenger N, Moraud EM, Raspopovic S, Bonizzato M, DiGiovanna J, Musienko P, Morari M, Micera S, Courtine G. Closed-loop neuromodulation of spinal sensorimotor circuits controls refined locomotion after complete spinal cord injury. // Science Transl Med. – 2014. – 6(255): 255ra133.
12. Capogrosso M., Wenger N., Raspopovic S., Musienko P., Beauparlant J., Bassi Luciani L., Courtine G., Micera S. A computational model for epidural electrical stimulation of spinal sensorimotor circuits // The Journal of Neuroscience. – 2013. – Т. 33. – №. 49. – С. 19326-19340.
12. Beauparlant J., van den Brand R., Barraud Q., Friedli L., Musienko P., Dietz V., Courtine G. Undirected compensatory plasticity contributes to neuronal dysfunction after severe sp3nal cord injury. Brain. 2013. Т. 136. №. 11. С. 3347-3361.
14. Musienko P.Е., Bogacheva I.N., Savochin A.А., Kilimnik V.A., Gorsky O.V., Nikitin O.А., Gerasimenko Y.P. Non-invasive transcutaneous spinal cord stimulation facilitates locomotor activity in decerebrated and spinal cats. Ross Fiziol Zh Im I M Sechenova. 2013. 99(8): 917-927. Russian.
15. Musienko P.E., Gorskiĭ O.V., Kilimnik V.A., Kozlovskaia I.B., Courtine G., Edgerton V.R., Gerasimenko Iu.P. Neuronal control of posture and locomotion in decerebrated and spinalized animals. Ross Fiziol Zh Im I M Sechenova. 2013. 99(3): 392-405. Russian.
16. Musienko P.E., Zelenin P.V., Lyalka V.F., Gerasimenko Y.P., Orlovsky G. N., & Deliagina T.G. Spinal and supraspinal control of the direction of stepping during locomotion . J Neurosci. 2012. 32(48):17442-17453.
17. van den Brand R, Heutschi J, Barraud Q, DiGiovanna J, Bartholdi K, Huerlimann M, Friedli L, Vollenweider I, Moraud EM, Duis S, Dominici N, Micera S, Musienko P, Courtine G. Restoring voluntary control of locomotion after paralyzing spinal cord injury. Science. 2012; 336(6085):1182-5.
18. Dominici N, Keller U, Vallery H, Friedli L, van den Brand R, Starkey ML, Musienko P, Riener R, Courtine G. Versatile robotic interface to evaluate, enable and train locomotion and balance after neuromotor disorders. Nat Med. 2012. 18(7):1142-1147.
19. Musienko P, Courtine G, Tibbs JE, Kilimnik V, Savochin A, Garfinkel A, Roy RR, Edgerton VR, Gerasimenko Y. Somatosensory control of balance during locomotion in decerebrated cat. J Neurophysiol. 2012;107(8):2072-82.
20. Musienko P, Heutschi J, Friedli L, den Brand RV, Courtine G. Multi-system neurorehabilitative strategies to restore motor functions following severe spinal cord injury. Exp Neurol. 2012 May;235(1):100-9.
21. Musienko P, van den Brand R, Märzendorfer O, Roy RR, Gerasimenko Y, Edgerton VR, Courtine G. Controlling specific locomotor behaviors through multidimensional monoaminergic modulation of spinal circuitries. J Neurosci. 2011;31(25):9264-78.
22. Vörös J, Larmagnac A, Courtine G, Musienko P “PDMS-Based Stretchable Multi-Electrode and Chemotrode Array for Epidural and Subdural Neuronal Recording, Electrical Stimulation and Drug Delivery”. Publication Date 22.12.2011. U.S. Patent №20130303873.
23. Courtine G, van den Brand R, Musienko P. Spinal cord injury: time to move. Lancet. 2011, 377(9781):1896-8.
24. Musienko PE, Zelenin PV, Orlovsky GN, Deliagina TG. Facilitation of postural limb reflexes with epidural stimulation in spinal rabbits. Neurophysiol. 2010, 03(2):1080-92.
25. Courtine G, Gerasimenko Y, van den Brand R, Yew A, Musienko P, Zhong H, Song B, Ao Y, Ichiyama RM, Lavrov I, Roy RR, Sofroniew MV, Edgerton VR. Transformation of nonfunctional spinal circuits into functional states after the loss of brain input. Nat Neurosci. 2009;12(10):1333-42.
26. Musienko P, van den Brand R, Maerzendorfer O, Larmagnac A, Courtine G.Combinatory electrical and pharmacological neuroprosthetic interfaces to regain motor function after spinal cord injury. IEEE Trans Biomed Eng. 2009;56(11 Pt 2):2707-11.
27. Bogacheva IN, Nikitin OA, Musienko PE, Savokhin AA, Gerasimenko IuP. Mechanisms of stepping rhythm formation during epidural spinal cord stimulation in decerebrated and spinal cord transected cats. Biofizika. 2009;54(3):529-36.
28. Gerasimenko Y, Musienko P, Bogacheva I, Moshonkina T, Savochin A, Lavrov I, Roy RR, Edgerton VR. Propriospinal bypass of the serotonergic system that can facilitate stepping. J Neurosci. 2009;29(17):5681-9
29. Musienko PE, Pavlova NV, Selionov VA, Gerasimenko IuP. Locomotion induced by epidural stimulation in decerebrate cat after spinal cord injury. Biofizika. 2009;54(2):293-300.
30. Musienko PE, Zelenin PV, Lyalka VF, Orlovsky GN, Deliagina TG. Postural performance in decerebrated rabbit. Behav Brain Res. 2008;190(1):124-34.
31. Lyalka VF, Musienko PE, Orlovsky GN, Grillner S, and Deliagina TG. Effect of intrathecal administration of serotoninergic and noradrenergic drugs on postural performance in rabbits with spinal cord lesions. J Neurophysiol. 2008;100(2):723-32.
32. Musienko PE, Bogacheva IN, Gerasimenko YP. Significance of peripheral feedback in the generation of stepping movements during epidural stimulation of the spinal cord. Neurosci. Behav. Physiol. 2007. Vol.37. N.2. P.181-190.
33. Bogacheva IN, Musienko PE, Gerasimenko YP. Mathematical modeling of the mechanisms of locomotor pattern formation under epidural spinal cord stimulation with consideration of peripheral feedback. Biofizika. 2005; 50(6):1125-30. Russian.
34. Gerasimenko Y, Lavrov I, Bogacheva I, Shcherbakova N, Kucher V, Musienko P. Formation of locomotor patterns in decerebrate cats in conditions of epidural stimulation of the spinal cord. Neurosci. Behav. Physiol. 2005. Vol.35. N.3. P.291-298.
35. Musienko PE, Bogacheva IN, Gerasimenko YP. Significance of peripheral feedback in stepping movement generation under epidural spinal cord stimulation. Ross Fiziol Zh Im I M Sechenova. 2005; 91(12): 1407-20. Russian.
36. Gerasimenko YP, Lavrov IA, Bogacheva IN, Shcherbakova NA, Kucher VI, Musienko PE. Features of stepping pattern formation in decerebrated cats under epidural spinal cord stimulation. Ross Fiziol Zh Im I M Sechenova. 2003; 89(9): 1046-57. Russian.
 
EU/US Patents:
 
“PDMS-Based Stretchable Multi-Electrode and Chemotrode Array for Epidural and Subdural Neuronal Recording, Electrical Stimulation and Drug Delivery”. Publication Date 22.12.2011. U.S. Patent №20130303873.
 
“Pharmacological stimulation to facilitate and restore standing and walking functions in spinal cord disorders".  Publication Date 7.01.2015. E.U. Patent №20130174477.